|
| |
 |
Overview
The cause of primary sclerosing cholangitis is not known. However there are several theories as to why damage to the bile duct occurs. Genetic abnormalities of the immune regulation, viral infection, toxins from intestinal bacteria, bacteria in the portal venous system, ischemic vascular damage, and toxic bile acids from intestinal bacteria are all factors that have been implicated in the pathogenesis of primary sclerosing cholangitis. Currently genetic and immunological factors are most favored to be responsible for the damage to the bile ducts. This is because there is a familial occurrence of this disease and an association with HLA-B8, DR3, DR2, and DR4. Evidence of abnormal immuno-regulation is evidenced by infiltration of the bile ducts with lymphocytes, increased serum gamma globulins, increased circulating immune complexes, and increased metabolism of complement C3 (Figure 8).  | | Figure 8. Summary of potential causative mechanisms of primary sclerosing cholangitis. |
Make an appointment today - call (410) 955-4166.
|
|
|
| |